Clinical

What is a p-value? The problem of hypothesis testing in observational studies

At a time when cost-effective, evidence-based care is increasingly demanded by patients, payers and our own professional organizations, research on outcomes of treatment has become more common. Over the past 10 years there has been a steady increase in the  levels of evidence reported in most of the journals read by hand surgeons. While this trend is encouraging in appearance,…

Clinical Practice Guidelines – Burden or Boon?

The American Academy of Orthopedic Surgeons (AAOS) has released a new Clinical Practice Guideline on the Diagnosis and Treatment of Carpal Tunnel Syndrome. This document replaces earlier ones on diagnosis, published in 2007, and treatment, which appeared in 2008. There was a widespread perception that the recommendations made in the previous guidelines were weak and did not contribute substantively to…
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